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引用本文:   覃诗雅, 陈南迪, 王青, 黄晋, 何晓晓, 刘剑波, 郭秋平, 羊小海, 王柯敏. 核酸适配体在多肽研究中的应用. 分析化学, 2017, 45(12): 1795-1803. doi:  10.11895/j.issn.0253-3820.170272 [复制]

Citation:   QIN Shi-Ya, CHEN Nan-Di, WANG Qing, HUANG Jin, HE Xiao-Xiao, LIU Jian-Bo, GUO Qiu-Ping, YANG Xiao-Hai, WANG Ke-Min. Application of Nucleic Acid Aptamers in Polypeptides Researches. Chinese Journal of Analytical Chemistry, 2017, 45(12): 1795-1803. doi: 10.11895/j.issn.0253-3820.170272 [复制]

核酸适配体在多肽研究中的应用

通讯作者:  羊小海, yangxiaohai@hnu.edu.cn; 王柯敏, kmwang@hnu.edu.cn

收稿日期: 2017-05-02

接受日期: 2017-09-03

出版日期: 2017-12-20

基金项目: 本文系国家自然科学基金项目(Nos.21675047,21375034,21190040,21521063)资助

Application of Nucleic Acid Aptamers in Polypeptides Researches

Corresponding author:  YANG Xiao-Hai, yangxiaohai@hnu.edu.cn; WANG Ke-Min, kmwang@hnu.edu.cn

Received Date:  2017-05-02

Accepted Date:  2017-09-03

Published Date:  2017-12-20

Fund Project:  This work was supported by the National Natural Science Foundation of China (Nos. 21675047, 21375034, 21190040, 21521063)

多肽在生命体的生理过程中发挥着重要作用,其生理功能一直是生物学、药理学和医学等领域的重要研究内容。核酸适配体是经体外筛选获得的单链DNA或RNA,能与靶标高亲和力、高特异性地结合,有"化学抗体"或"化学家的抗体"之称。以多肽为靶标筛选获得的核酸适配体主要有两大用途:一是基于其识别功能,作为亲和试剂来建立分析检测方法或开展生物成像研究;二是基于它们的生物学活性,作为拮抗剂在活体水平影响靶标多肽的正常功能,阻碍下游信号通路,从而对疾病进行治疗。本文总结了近年来以多肽为靶标筛选的核酸适配体在体内及体外的用途,并探讨了其在筛选、表征及应用中存在的问题,并对其未来的发展趋势进行了展望。

关键词:   多肽, 核酸适配体, 分析检测, 生物成像, 拮抗剂, 评述
Key words:   Polypeptides, Aptamers, Analytical methods, Biological imaging, Antagonists, Review
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核酸适配体在多肽研究中的应用

覃诗雅, 陈南迪, 王青, 黄晋, 何晓晓, 刘剑波, 郭秋平, 羊小海, 王柯敏

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