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引用本文:   刘杨, 邹笑然, 李琛琛, 张春阳. 激酶检测方法的最新研究进展. 分析化学, 2018, 46(1): 11-19. doi:  10.11895/j.issn.0253-3820.171275 [复制]

Citation:   LIU Yang, ZOU Xiao-Ran, LI Chen-Chen, ZHANG Chun-Yang. Recent Advances in Sensitive Detection of Kinases. Chinese Journal of Analytical Chemistry, 2018, 46(1): 11-19. doi: 10.11895/j.issn.0253-3820.171275 [复制]

激酶检测方法的最新研究进展

通讯作者:  张春阳, cyzhang@sdnu.edu.cn

收稿日期: 2017-09-27

接受日期: 2017-11-07

出版日期: 2018-01-20

基金项目: 本文系国家杰出青年科学基金项目(No.21325523)和科技部重点领域创新团队项目(No.2015RA4024)资助

Recent Advances in Sensitive Detection of Kinases

Corresponding author:  ZHANG Chun-Yang, cyzhang@sdnu.edu.cn

Received Date:  2017-09-27

Accepted Date:  2017-11-07

Published Date:  2018-01-20

Fund Project:  This work was supported by the National Science Foundation for Distinguished Young Scholars of China (No. 21325523)

激酶是生物体内一类重要的磷酸转移酶,能够催化磷酸基团由高能磷酸基团供体分子(如ATP)向特定底物分子转移。激酶不但在新陈代谢、细胞信号传导、蛋白质调控、细胞传输等过程中起着关键作用,而且在临床诊断、药物研发及疾病靶向治疗等方面也发挥着重要作用。因此,发展灵敏度高、特异性好的激酶检测方法十分必要。本文以蛋白激酶A(Protein kinase A,PKA)、酪蛋白激酶(Casein kinase-2,CKII)、T4多核苷酸激酶(T4 polynucleotide kinase,T4 PNK)为例,对近年来发展的激酶检测方法进行了综述,着重介绍了荧光分析法、单分子检测、比色法、化学发光和生物发光分析法、电化学和光电化学分析法,并对激酶检测方法的发展方向进行了展望。

关键词:   激酶, 灵敏检测, 分析方法, 评述
Key words:   Kinases, Sensitive detection, Analytical methods, Review
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激酶检测方法的最新研究进展

刘杨, 邹笑然, 李琛琛, 张春阳

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