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引用本文:   张雯, 张娇, 李平, 张卫, 肖海滨, 唐波. 荧光/化学发光探针成像检测超氧阴离子自由基的研究进展. 分析化学, 2017, 45(12): 1838-1844. doi:  10.11895/j.issn.0253-3820.171334 [复制]

Citation:   ZHANG Wen, ZHANG Jiao, LI Ping, ZHANG Wei, XIAO Hai-Bin, TANG Bo. Recent Advances in Fluorescent Probes for Imaging of Superoxide Anion Radical. Chinese Journal of Analytical Chemistry, 2017, 45(12): 1838-1844. doi: 10.11895/j.issn.0253-3820.171334 [复制]

荧光/化学发光探针成像检测超氧阴离子自由基的研究进展

通讯作者:  李平, lip@sdnu.edu.cn; 唐波, tangb@sdnu.edu.cn

收稿日期: 2017-10-13

接受日期: 2017-11-02

出版日期: 2017-12-20

基金项目: 本文系国家自然科学基金项目(Nos.21390411,21535004,21475079,21675105,2170050332)和山东省自然科学基金项目(No.ZR2017BB066)资助

Recent Advances in Fluorescent Probes for Imaging of Superoxide Anion Radical

Corresponding author:  LI Ping, lip@sdnu.edu.cn; TANG Bo, tangb@sdnu.edu.cn

Received Date:  2017-10-13

Accepted Date:  2017-11-02

Published Date:  2017-12-20

Fund Project:  This work was supported by the National Natural Science Foundation of China (Nos. 21390411, 21535004, 21475079, 21675105, 2170050332) and the Natural Science Foundation of Shandong Province, China (No. ZR2017BB066)

超氧阴离子自由基(O2·-)是细胞内氧气单电子还原后最先产生的一类含氧的高活性物种(活性氧,ROS),与生命过程息息相关。正常稳态浓度的O2·-起重要的信号调控作用,包括细胞的增殖、分化、自噬等。但O2·-浓度的异常,又与癌症、神经退行性疾病、糖尿病等多种疾病的发生发展密切相关。因此,监测O2·-浓度的变化对揭示相关疾病的机理具有至关重要作用。由于荧光成像检测方法具有诸多优势,发展高灵敏、高选择性检测O2·-的荧光探针成为揭示相关疾病发生发展分子机制的关键切入点。近年来,随着荧光显微技术的发展,研究者开发了多种荧光/化学发光探针,实现了对细胞及活体内O2·-水平的可视化监测。本文综述了近五年用于检测O2·-的分子探针、纳米探针、蛋白探针以及化学发光探针的研究进展,并对其发展前景进行了展望。

关键词:   超氧阴离子自由基, 荧光探针, 化学发光探针, 活细胞成像, 评述
Key words:   Superoxide anion radical, Fluorescent probe, Chemiluminescence probe, Live cell imaging, Review
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荧光/化学发光探针成像检测超氧阴离子自由基的研究进展

张雯, 张娇, 李平, 张卫, 肖海滨, 唐波

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