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引用本文:   堵玉林, 莫柳婷, 易娅莎, 邱丽萍, 谭蔚泓. 基于Cell-SELEX的核酸适配体在生化分析与生物成像中的应用. 分析化学, 2017, 45(12): 1757-1765. doi:  10.11895/j.issn.0253-3820.171337 [复制]

Citation:   DU Yu-Lin, MO Liu-Ting, YI Ya-Sha, QIU Li-Ping, TAN Wei-Hong. Aptamers from Cell-based Selection for Bioanalysis and Bioimaging. Chinese Journal of Analytical Chemistry, 2017, 45(12): 1757-1765. doi: 10.11895/j.issn.0253-3820.171337 [复制]

基于Cell-SELEX的核酸适配体在生化分析与生物成像中的应用

通讯作者:  邱丽萍, qiuliping@hnu.edu.cn; 谭蔚泓, tan@chem.ufl.edu

收稿日期: 2017-10-15

接受日期: 2017-10-26

出版日期: 2017-12-20

Aptamers from Cell-based Selection for Bioanalysis and Bioimaging

Corresponding author:  QIU Li-Ping, qiuliping@hnu.edu.cn; TAN Wei-Hong, tan@chem.ufl.edu

Received Date:  2017-10-15

Accepted Date:  2017-10-26

Published Date:  2017-12-20

基于Cell-SELEX的核酸适配体是指以活细胞为靶标物,通过指数富集的配基系统进化技术(Systematic evolution of ligands by exponential enrichment,SELEX)从人工合成的DNA/RNA文库中筛选得到的单链寡核苷酸。它能够与靶标细胞高亲和性、高特异性结合,具有分子量低、合成简单、化学稳定性好、免疫原性低、易于功能化修饰等优点,已广泛应用于生命科学研究领域。本文综述了基于Cell-SELEX技术筛选的核酸适配体在肿瘤细胞检测、分析和成像方面的研究进展,并对核酸适配体研究的发展前景和趋势进行了展望。

关键词:   核酸适配体, Cell-SELEX, 生化分析, 生物成像, 肿瘤细胞,  
Key words:   Aptamer, Cell-SELEX, Bioanalysis, Bioimaging, Tumor cells, Review
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基于Cell-SELEX的核酸适配体在生化分析与生物成像中的应用

堵玉林, 莫柳婷, 易娅莎, 邱丽萍, 谭蔚泓

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