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引用本文:   李淋雨, 王晓英. Tau蛋白的分析方法研究进展. 分析化学, 2020, 48(6): 685-694. doi:  10.19756/j.issn.0253-3820.191379 [复制]

Citation:   LI Lin-Yu , WANG Xiao-Ying . Progress in Analysis of Tau Protein. Chinese Journal of Analytical Chemistry, 2020, 48(6): 685-694. doi: 10.19756/j.issn.0253-3820.191379 [复制]

Tau蛋白的分析方法研究进展

收稿日期: 2019-07-06

基金项目: 本文系国家自然科学基金项目(Nos.81573313,81302472)和江苏省高校"青蓝工程"项目资助

Progress in Analysis of Tau Protein

Received Date:  2019-07-06

Fund Project:  This work was supported by the National Natural Science Foundation of China (Nos. 81573313, 81302472) and the "Blue Project" Funded by Universities in Jiangsu Province, China.

Tau蛋白(简称Tau)是一种参与神经系统发育的微管相关蛋白。Tau可经历构象改变、异常mRNA剪接等,从微管解离,经系列翻译后修饰(Post-translational modification,PTM),自身形成病理性聚集,进而造成神经退行性病变,最终形成Tau病。研究Tau的病理过程,分析评估其PTM及定量检测其浓度变化,对Tau病的早期诊断、跟踪、预防和治疗具有重要意义。本文对目前Tau的常规分析方法进行了概述和比较,重点阐述光学、电化学生物传感方法的最新研究进展与相关应用,对未来发展方向进行了展望,为Tau蛋白的深入研究与应用提供参考。

关键词:   Tau蛋白, Tau病, 生物传感器, 翻译后修饰, 评述
Key words:   Tau protein, Tauopathies, Biosensor, Post-translational modification, Review
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Tau蛋白的分析方法研究进展

李淋雨, 王晓英

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