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引用本文:   罗彦波, 陈小静, 李翔宇, 张洪非, 朱风鹏, 姜兴益, 庞永强. 化学衍生-液相色谱-串联质谱法测定加热卷烟烟气中的醛酮类香味成分. 分析化学, 2020, 48(6): 794-801. doi:  10.19756/j.issn.0253-3820.201049 [复制]

Citation:   LUO Yan-Bo , CHEN Xiao-Jing , LI Xiang-Yu , ZHANG Hong-Fei , ZHU Feng-Peng , JIANG Xing-Yi , PANG Yong-Qiang . Determination of Aldehyde and Ketone Flavor Compounds in Mainstream Smoke of Heated Tobacco Products by Chemical Derivatization-Liquid Chromatography-Tandem Mass Spectrometry. Chinese Journal of Analytical Chemistry, 2020, 48(6): 794-801. doi: 10.19756/j.issn.0253-3820.201049 [复制]

化学衍生-液相色谱-串联质谱法测定加热卷烟烟气中的醛酮类香味成分

收稿日期: 2020-01-19

基金项目: 本文系国家烟草质量监督检验中心科技创新项目(No.512018CA0050)资助

Determination of Aldehyde and Ketone Flavor Compounds in Mainstream Smoke of Heated Tobacco Products by Chemical Derivatization-Liquid Chromatography-Tandem Mass Spectrometry

Received Date:  2020-01-19

Fund Project:  This work was supported by the Science Innovation Foundation of China National Tobacco Quality and Supervision & Test Center (No.512018CA0050).

建立了化学衍生结合液相色谱-串联质谱(LC-MS/MS)检测加热卷烟烟气中9种醛酮类香味成分的分析方法。样品和标准溶液中的目标分析物分别用1-(2-肼基-2-氧代乙基)吡啶-1-溴化物(吉拉德P试剂,GP)和d5-GP衍生,以标准溶液的衍生化产物作为稳定同位素内标,采用多反应监测模式检测。在最优的衍生化反应条件下,9种醛酮类香味成分在各自浓度范围内线性关系良好,标准曲线相关系数(R2)≥0.9937,检出限为0.07~12.66 ng/mL,相对标准偏差为0.2%~11.6%。9种醛酮类香味成分在3个加标水平下的回收率为82.5%~118.0%。本方法可用于加热卷烟烟气中醛酮类香味成分的检测。

关键词:   化学衍生, 液相色谱-串联质谱, 加热卷烟, 醛酮类香味成分
Key words:   Chemical derivatization, Liquid chromatography-tandem mass spectrometry, Heated tobacco product, Aldehyde and ketone flavor compounds
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目录

化学衍生-液相色谱-串联质谱法测定加热卷烟烟气中的醛酮类香味成分

罗彦波, 陈小静, 李翔宇, 张洪非, 朱风鹏, 姜兴益, 庞永强

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