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《分析化学》编委风采--颜晓梅

来源:分析化学 阅读数:258 时间:2020-04-29 16:41:07

对读者的一句话

愿分析化学能为前沿探索提供更多的研发利器,为社会经济发展和人民生活水平提高提供更强的技术保障。分析化学集方法、技术、仪器、和试剂为一体,顶天立地,大有可为。


个人简介



颜晓梅,厦门大学特聘教授、国家杰出青年科学基金获得者、国家“万人计划”科技创新领军人才。1986-1990年厦门大学科学仪器工程系本科;1990-1996年厦门大学/日本名古屋大学联合培养,获分析化学博士学位;1996-1997年美国佛罗里达大学化学系博士后;1997-2005年美国Los Alamos National Laboratory(洛斯阿拉莫斯国家实验室)生物科学部博士后、研究员(独立PI)。2005年8月起任职厦门大学化学化工学院教授、博士生导师,2008-2018年担任化学生物学系创系系主任。主要研究领域为生物分析技术与仪器,主持国家重大科研仪器研制项目和基金委重点项目、科学仪器基础研究专款等国家级项目10余项,在Annu.Rev. Anal. Chem., J. Am. Chem. Soc., Angew.Chem. Int. Ed., ACS Nano, Anal. Chem.等期刊发表SCI论文90余篇。所领导的课题组研发成功具有自主知识产权的纳米流式检测技术,实现单个纳米颗粒(7-500nm)以及外泌体、病毒、细菌、亚细胞结构等天然生物纳米颗粒的粒径及其分布、颗粒浓度、和生物化学性状的高灵敏、高选择性、高通量检测,填补了国际空白。“纳米流式检测技术”研发成果已由厦门福流生物科技有限公司成功转化为“中国智造”,所生产的纳米流式检测仪出口到全球顶尖的医疗机构、科研单位和高科技企业,如梅奥医学中心MayoClinic、德州大学安德森癌症中心MD Anderson Cancer Center、约翰霍普金斯大学医学院、Codiak BioSciences、悉尼大学、台湾大学等,在高端科研仪器的制造领域点下了一笔艳丽的“中国色彩”。


负责审阅的领域 

生化分析与生物传感,单分子、单颗粒、单细胞分析


近期研究成果

  1. 1.He, SB; Hong, XY; Zhang, MM; Wu, LN; Yan, XM*, Label-Free Detection of Bacteria in Fruit Juice byNano-Flow Cytometry, Anal. Chem. 2020,92, 2393-2400.

  2. 2.Tian, Y; Gong, MF; Hu, YY; Liu, HS; Zhang, WQ; Zhang MM; Hu, XX,Aubert, D; Zhu, SB; Wu, LN; Yan, XM*,Quality and Efficiency Assessment of Six Extracellular Vesicle IsolationMethods by Nano-Flow Cytometry, J.Extracell. Vesicles 2020, 9, 1697028.

  3. 3.Lian, H; He, SB; Chen, CX; Yan,XM*, Flow Cytometric Analysis of Nanoscale Biological Particles andOrganelles, Annu. Rev. Anal. Chem. 2019,12, 389-409.

  4. 4.Wu, LN*; Zhang, MM; Song, YY; Deng, MF; He, SB; Su, LQ; Chen, Y;Wood, T. K.; Yan, XM*, Decipheringthe Antitoxin-Regulated Bacterial Stress Response via Single-Cell Analysis, ACS Chem. Biol. 2019, 14, 122859-122866.

  5. 5.Chen, CX*; Gao, KM; Lian, H; Chen, C; Yan, XM*, Single-Particle Characterization of Theranostic Liposomeswith Stimulus Sensing and Controlled Drug Release Properties, Biosens. Bioelectron. 2019, 131,185-192.

  6. 6.Gao, M; Lian, H; Yu, LJ; Gong, MF; Ma, L; Zhou, YX; Yu, MX; Yan, XM*, Rolling Circle Amplification Integrated with Suspension Bead Arrayfor Ultrasensitive Multiplex Immunodetection of Tumor Markers, Anal. Chim. Acta, 2019, 1048, 75-84.

  7. 7.Tian, Y; Ma, L; Gong, MF; Su, GQ*, Zhu, SB; Zhang, WQ; Wang, S; LiZB; Chen CX; Li, LH; Wu, LN; Yan, XM*,Protein Profiling and Sizing of Extracellular Vesicles from Colorectal CancerPatients via Flow Cytometry, ACS Nano2018, 12, 671-680.

  8. 8.Zhang, WQ; Tian, Y; Hu, XX; He, SB; Niu, Q; Chen, CX; Zhu, SB; Yan, XM*, Light-Scattering Sizing ofSingle Submicron Particles by High-Sensitivity Flow Cytometry, Anal. Chem. 2018, 90, 12768-12775.

  9. 9.Wang, S; Li, LH; Jin, SH; Li, WF; Hang, W; Yan, XM*, Rapid and Quantitative Measurement of Single Quantum Dotsin a Sheath Flow Cuvette, Anal. Chem.2017, 89, 9857-9867.

  10. 10.Wu, LN; Wang, X; Zhang, JQ; Luan, T; Bouveret, E.; Yan, XM*, Flow Cytometric Single-Cell AnalysisEnables Quantitative in vivo Detection of Protein-Protein Interactions via RelativeReporter Protein Expression Measurement, Anal.Chem. 2017, 89, 2782-2789.

  11. 11.Chen, CX; Zhu, SB; Wang, S; Zhang, WQ; Cheng, Y; Yan, XM*, Multiparameter Quantificationof Liposomal Nanomedicines at the Single-particle Level by High SensitivityFlow Cytometry, ACS Appl. Mater.Interfaces 2017, 9, 13913-13919.

  12. 12.Yan, Y; Meng, LY; Zhang, WQ; Zheng, Y; Wang, S; Ren, B; Yang, ZL*; Yan, XM*, High-ThroughputSingle-Particle Analysis of Metal-Enhanced Fluorescence in Free Solution UsingAg@SiO2 Core-Shell Nanoparticles, ACS Sensors 2017, 2, 1369-1376.

  13. 13.Ma, L; Zhu, SB; Tian, Y; Zhang, WQ; Wang, S; Chen, CX; Wu, LN; Yan, XM*, A Label-Free Analysis of SingleViruses with a Resolution Comparable to That of Electron Microscopy and the Throughputof Flow Cytometry, Angew. Chem. Int. Ed.2016, 55, 10239–10243. (Hot Paper)

  14. 14.Wu, LN; Song, YY; Luan, T; Ma, L; Su, LQ; Wang, S; Yan XM*, Specific Detection of Live Escherichia coli O157:H7 UsingTetracysteine-Tagged PP01 Bacteriophage, Biosens.Bioelectron. 2016, 86, 102-108.

  15. 15.Huang, TX; Zheng, Y; Yan, Y; Yang, LL; Yao, YH; Zheng, JX; Wu, LN;Wang, X; Chen, YQ; Xing, JC; Yan, XM*,Probing Minority Population of Antibiotic-Resistant Bacteria, Biosens. Bioelectron. 2016, 80, 323-330.

  16. 16.Wu, LN; Wang, S; Song, YY; Wang, X; Yan, XM*. Applications and Challenges for Single-Bacteria Analysisby Flow Cytometry, Sci. China Chem.2016, 59, 30-39.

  17. 17.Chen, CX; Zhang, X; Zhang, SY; Zhu, SB; Xu, JY, Zheng, Y; Han, JY,Zeng, JZ; Yan, XM*, Quantificationof protein copy number in single mitochondria: the Bcl-2 family proteins, Biosens. Bioelectron. 2015, 74, 476-482.

  18. 18.Zhu, SB; Ma, L; Wang, S; Chen, CX; Zhang, WQ; Yang, LL; Hang, W;Nolan, J. P.; Wu, LN; Yan, XM*, Light-ScatteringDetection below the Level of Single Fluorescent Molecules for High-Resolution Characterizationof Functional Nanoparticles. ACS Nano2014, 8, 10998-11006.

  19. 19.Zhang, X; Zhang, SY; Zhu, SB; Chen, S; Han, JY; Gao, KM; Zeng, JZ; Yan, XM*, Rapid identification ofmitochondria-targeting anticancer compounds by an in vitro strategy, Anal. Chem. 2014, 86, 5232−5237.

  20. 20.Wu, LN; Luan, T; Yang, XT; Wang, S; Zheng, Y; Huang, TX; Zhu, SB; Yan, XM*, Trace detection of specific viablebacteria using tetracysteine-tagged bacteriophages, Anal. Chem. 2014, 86, 907-912.


在《分析化学》发表的论文

  1. 1.高恺旻,颜晓梅.生物制药领域蛋白质团聚检测技术的研究进展[J].分析化学,2018,46(10):1507-1517.

    http://www.analchem.cn/article/doi/10.11895/j.issn.0253-3820.181280

  2. 2.韩锦艳,许静怡,张翔,周颖星,陈超翔,颜晓梅.线粒体荧光标记的单颗粒水平高通量评估方法[J].分析化学,2016,44(08):1171-1177.

    http://www.analchem.cn/article/doi/10.11895/j.issn.0253-3820.160102

  3. 3.许静怡,陈超翔,韩锦艳,杭纬,颜晓梅.线粒体蛋白质组学研究进展[J].分析化学,2015,43(09):1257-1264.

    http://www.analchem.cn/article/doi/10.11895/j.issn.0253-3820.150479